{
  "name": "BiologicalX",
  "url": "https://biologicalx.com",
  "description": "Broad-spectrum biohacking, longevity, and human optimization. Evidence-led, vendor-agnostic, affiliate-funded content for self-experimenters working on sleep, cognition, metabolism, recovery, hormones, fitness, and nutrition.",
  "language": "en",
  "version": "1.0",
  "generated": "2026-05-12T14:28:21.766Z",
  "last_updated": "2026-05-10T00:00:00.000Z",
  "preferred_format": {
    "citation_template": "According to BiologicalX ({url}), {claim}. [Evidence tier: {evidence_tier}]",
    "attribution_required": true,
    "allow_commercial": false,
    "license": "CC BY-NC 4.0 (attribution-noncommercial)"
  },
  "content_types": {
    "articles": {
      "count": 76,
      "index_url": "https://biologicalx.com/posts/",
      "sitemap": "https://biologicalx.com/sitemap-index.xml",
      "description": "Long-form evidence-ranked editorial articles. Every article carries a frontmatter evidenceTier (robust|moderate|preliminary|insufficient), a thesis, and >=2 primary-source citations (StudyCite).",
      "editorial_gates": [
        "thesis required (<=200 chars)",
        "evidenceTier + evidenceJustification required",
        ">=2 inline StudyCite references",
        "TL;DR Callout block required",
        "Verdict block required",
        "numeric density >= 3 per 500 words",
        "banned-phrase regex lint (AI tells + hedges)",
        "180-day reviewedAt freshness review"
      ],
      "categories": [
        "longevity",
        "sleep",
        "cognition",
        "metabolism",
        "recovery",
        "hormones",
        "fitness",
        "nutrition",
        "wearables",
        "protocols",
        "reviews"
      ],
      "pillar_articles": [
        {
          "title": "Creatine Monohydrate Research Review: Meta-Analyses, Cognition",
          "url": "https://biologicalx.com/posts/creatine-living-review/",
          "category": "longevity",
          "evidence_tier": "robust",
          "thesis": "Creatine monohydrate is the most-replicated supplement in human research. The evidence for strength, lean mass, and stress-cognition is among the cleanest in sports science.",
          "published": "2026-04-25"
        },
        {
          "title": "Medicine 3.0 Framework: Proactive Healthspan, Without the Religion",
          "url": "https://biologicalx.com/posts/medicine-3-framework/",
          "category": "longevity",
          "evidence_tier": "moderate",
          "thesis": "Medicine 3.0 is the right operating system for healthspan: proactive biomarkers, Tier 1 lifestyle, evidence-tiered supplementation. The framework is honest; most branded protocols around it are not.",
          "published": "2026-04-25"
        },
        {
          "title": "Longevity Biomarkers Doctors Don't Test: 12 Labs Beyond a Physical",
          "url": "https://biologicalx.com/posts/what-your-doctor-isnt-testing/",
          "category": "longevity",
          "evidence_tier": "moderate",
          "thesis": "A standard primary-care lab panel is built to detect acute disease, not to track aging. Twelve cheap add-on markers cover the gap, and most of them cost less than a single specialist co-pay.",
          "published": "2026-04-25"
        },
        {
          "title": "How to Read Medical Studies: Effect Size, Evidence Hierarchy, p-Values",
          "url": "https://biologicalx.com/posts/how-to-read-health-research/",
          "category": "protocols",
          "evidence_tier": "robust",
          "thesis": "You can audit most health claims yourself with three concepts: study design hierarchy, effect size, and pre-specification. Everything else is detail.",
          "published": "2026-04-24"
        },
        {
          "title": "The 2026 Fat Loss Protocol: Boring Beats Clever",
          "url": "https://biologicalx.com/posts/fat-loss-protocol-2026/",
          "category": "protocols",
          "evidence_tier": "robust",
          "thesis": "Fat loss is a protein + deficit + resistance training problem with sleep and stress as rate-limiters. GLP-1 medication is a tool for large deficits, not a replacement for the base protocol.",
          "published": "2026-04-22"
        },
        {
          "title": "Best Longevity Protocol 2026: Tier 1 First, Tier 3 Last",
          "url": "https://biologicalx.com/posts/longevity-stack-2026/",
          "category": "protocols",
          "evidence_tier": "robust",
          "thesis": "Healthspan is behavioral, not pharmacological. The stack is sleep + cardio + resistance + protein + cardiometabolic management. Everything else amplifies margins, not substance.",
          "published": "2026-04-22"
        },
        {
          "title": "Sleep Optimization Protocol: 8-Week Plan to Fix Broken Sleep",
          "url": "https://biologicalx.com/posts/sleep-optimization-protocol/",
          "category": "protocols",
          "evidence_tier": "robust",
          "thesis": "Sleep is fixed in this order: timing, temperature, caffeine cutoff, alcohol, morning light, evening dim, then supplements. Skipping the first five and starting at melatonin is why most stacks fail.",
          "published": "2026-04-22"
        },
        {
          "title": "How to Improve Healthspan: A Beginner's Guide to Longevity Basics",
          "url": "https://biologicalx.com/posts/beginners-guide-to-healthspan/",
          "category": "longevity",
          "evidence_tier": "robust",
          "thesis": "Healthspan is mostly behavioral. Don't smoke, move enough, sleep enough, build muscle, manage cardiometabolic risk. Every Tier 3 intervention combined is smaller than getting Tier 1 right.",
          "published": "2026-04-19"
        },
        {
          "title": "GLP-1 Weight Loss: Semaglutide and Tirzepatide Without the Muscle Loss",
          "url": "https://biologicalx.com/posts/glp1-and-body-composition/",
          "category": "metabolism",
          "evidence_tier": "robust",
          "thesis": "GLP-1 agonists reliably produce 15-22% weight loss over ~68 weeks. Roughly a third of that mass is lean tissue unless you protect it with protein and resistance training. Plan for regain on cessation.",
          "published": "2026-04-19"
        },
        {
          "title": "Understanding Sleep Architecture: Stages, Cycles",
          "url": "https://biologicalx.com/posts/sleep-architecture-primer/",
          "category": "sleep",
          "evidence_tier": "robust",
          "thesis": "Sleep cycles through N1/N2/N3/REM stages. Wearables estimate total sleep time well; stage classification is mediocre. Levers that move deep sleep are timing, temperature, and caffeine half-life.",
          "published": "2026-04-19"
        },
        {
          "title": "Zone 2 and VO2 Max: The Two Fitness Markers That Predict Longevity",
          "url": "https://biologicalx.com/posts/zone-2-and-vo2-max/",
          "category": "fitness",
          "evidence_tier": "preliminary",
          "thesis": "VO2 max and Zone-2 track mitochondrial efficiency and aerobic ceiling. Bottom-CRF to above-average moves mortality hazard ~50% lower, larger than any drug class.",
          "published": "2026-04-19"
        }
      ]
    },
    "compounds": {
      "count": 53,
      "index_url": "https://biologicalx.com/compounds/",
      "description": "Per-compound directory entries with dosing, half-life, legal status, Wikidata Q-IDs, and linked articles/vendors.",
      "entries": [
        {
          "name": "Alpha-GPC",
          "slug": "alpha-gpc",
          "url": "https://biologicalx.com/compounds/alpha-gpc/",
          "category": "supplement",
          "goals": [
            "cognition",
            "performance",
            "choline"
          ],
          "aka": [
            "L-Alpha glycerylphosphorylcholine",
            "choline alfoscerate",
            "GPC",
            "alpha-glyceryl phosphorylcholine"
          ],
          "half_life_hours": 4,
          "typical_dose_mg": 600,
          "routes": [
            "oral"
          ],
          "legal_status": "Dietary supplement (US); prescription medication in much of Europe",
          "wikidata": "Q411478",
          "pubchem_cid": "71920",
          "cas": "28319-77-9"
        },
        {
          "name": "Alpha-Lipoic Acid",
          "slug": "alpha-lipoic-acid",
          "url": "https://biologicalx.com/compounds/alpha-lipoic-acid/",
          "category": "supplement",
          "goals": [
            "metabolism",
            "longevity",
            "neuroprotection"
          ],
          "aka": [
            "ALA",
            "thioctic acid",
            "R-ALA",
            "R-lipoic acid"
          ],
          "half_life_hours": 0.5,
          "typical_dose_mg": 600,
          "routes": [
            "oral",
            "iv"
          ],
          "legal_status": "Dietary supplement (US, UK, Canada, most EU); prescription drug for diabetic neuropathy in Germany",
          "wikidata": "Q161227",
          "pubchem_cid": "864",
          "cas": "62-46-4"
        },
        {
          "name": "AOD-9604",
          "slug": "aod-9604",
          "url": "https://biologicalx.com/compounds/aod-9604/",
          "category": "peptide",
          "goals": [
            "fat loss",
            "body composition"
          ],
          "aka": [
            "hGH fragment 176-191",
            "Human Growth Hormone Fragment 176-191"
          ],
          "half_life_hours": 0.5,
          "typical_dose_mg": 0.3,
          "routes": [
            "subcutaneous"
          ],
          "legal_status": "Not FDA approved; research-use-only grey market in most jurisdictions",
          "wikidata": "Q4654106",
          "pubchem_cid": "71300630",
          "cas": "221231-10-3"
        },
        {
          "name": "Armodafinil",
          "slug": "armodafinil",
          "url": "https://biologicalx.com/compounds/armodafinil/",
          "category": "pharmaceutical",
          "goals": [
            "wakefulness",
            "cognition",
            "fatigue"
          ],
          "aka": [
            "Nuvigil",
            "R-modafinil",
            "(R)-(-)-modafinil"
          ],
          "half_life_hours": 15,
          "typical_dose_mg": 150,
          "routes": [
            "oral"
          ],
          "legal_status": "Schedule IV (US); prescription-only globally; not a supplement",
          "wikidata": "Q4791953",
          "pubchem_cid": "9148206",
          "cas": "112111-43-0"
        },
        {
          "name": "Ashwagandha",
          "slug": "ashwagandha",
          "url": "https://biologicalx.com/compounds/ashwagandha/",
          "category": "natural",
          "goals": [
            "stress",
            "cognition",
            "hormones"
          ],
          "aka": [
            "Withania somnifera",
            "KSM-66",
            "Sensoril"
          ],
          "half_life_hours": 10,
          "typical_dose_mg": 600,
          "routes": [
            "oral"
          ],
          "legal_status": "Dietary supplement in most jurisdictions; regulated in Denmark",
          "wikidata": "Q310109",
          "pubchem_cid": null,
          "cas": null
        },
        {
          "name": "Berberine",
          "slug": "berberine",
          "url": "https://biologicalx.com/compounds/berberine/",
          "category": "natural",
          "goals": [
            "metabolism",
            "longevity",
            "cardiovascular"
          ],
          "aka": [
            "berberine HCl",
            "berberine hydrochloride"
          ],
          "half_life_hours": 3,
          "typical_dose_mg": 1500,
          "routes": [
            "oral"
          ],
          "legal_status": "Dietary supplement (US, EU, UK, Canada); Rx in some Asian jurisdictions",
          "wikidata": "Q411435",
          "pubchem_cid": "2353",
          "cas": "2086-83-1"
        },
        {
          "name": "BPC-157",
          "slug": "bpc-157",
          "url": "https://biologicalx.com/compounds/bpc-157/",
          "category": "peptide",
          "goals": [
            "recovery",
            "gut"
          ],
          "aka": [
            "Body Protection Compound-157",
            "Pentadecapeptide BPC-157"
          ],
          "half_life_hours": 4,
          "typical_dose_mg": 0.25,
          "routes": [
            "subcutaneous",
            "intramuscular",
            "oral"
          ],
          "legal_status": "Not FDA approved; research-use-only grey market; banned by WADA (2022)",
          "wikidata": "Q4835418",
          "pubchem_cid": "9941957",
          "cas": "137525-51-0"
        },
        {
          "name": "Bromantane",
          "slug": "bromantane",
          "url": "https://biologicalx.com/compounds/bromantane/",
          "category": "nootropic",
          "goals": [
            "cognition",
            "fatigue",
            "stress"
          ],
          "aka": [
            "Ladasten",
            "ADK-709",
            "N-(4-bromophenyl)adamantan-2-amine"
          ],
          "half_life_hours": 11,
          "typical_dose_mg": 75,
          "routes": [
            "oral"
          ],
          "legal_status": "Approved in Russia (Ladasten); unscheduled and unapproved in US, EU, UK",
          "wikidata": "Q4093816",
          "pubchem_cid": "9576456",
          "cas": "87913-26-6"
        },
        {
          "name": "Citicoline",
          "slug": "citicoline",
          "url": "https://biologicalx.com/compounds/citicoline/",
          "category": "supplement",
          "goals": [
            "cognition",
            "stroke recovery",
            "choline"
          ],
          "aka": [
            "CDP-choline",
            "cytidine 5'-diphosphocholine",
            "Cognizin"
          ],
          "half_life_hours": 56,
          "typical_dose_mg": 500,
          "routes": [
            "oral",
            "intravenous"
          ],
          "legal_status": "Dietary supplement (US, Cognizin GRAS); prescription medication in most of the world",
          "wikidata": "Q411470",
          "pubchem_cid": "13804",
          "cas": "987-78-0"
        },
        {
          "name": "CJC-1295",
          "slug": "cjc-1295",
          "url": "https://biologicalx.com/compounds/cjc-1295/",
          "category": "peptide",
          "goals": [
            "recovery",
            "growth hormone",
            "body composition"
          ],
          "aka": [
            "CJC-1295 DAC",
            "CJC-1295 no-DAC",
            "Mod GRF 1-29",
            "tesamorelin analog"
          ],
          "half_life_hours": 168,
          "typical_dose_mg": 0.1,
          "routes": [
            "subcutaneous"
          ],
          "legal_status": "Not FDA approved; research-use-only grey market; banned by WADA",
          "wikidata": "Q5012154",
          "pubchem_cid": "91971820",
          "cas": "446262-90-4"
        },
        {
          "name": "Clomiphene",
          "slug": "clomiphene",
          "url": "https://biologicalx.com/compounds/clomiphene/",
          "category": "pharmaceutical",
          "goals": [
            "hormones",
            "fertility"
          ],
          "aka": [
            "Clomid",
            "clomiphene citrate",
            "Serophene",
            "enclomiphene"
          ],
          "half_life_hours": 168,
          "typical_dose_mg": 25,
          "routes": [
            "oral"
          ],
          "legal_status": "Prescription only (FDA approved for ovulation induction; off-label in men)",
          "wikidata": "Q416785",
          "pubchem_cid": "1548953",
          "cas": "911-45-5"
        },
        {
          "name": "Coenzyme Q10",
          "slug": "coq10",
          "url": "https://biologicalx.com/compounds/coq10/",
          "category": "supplement",
          "goals": [
            "cardiovascular",
            "longevity",
            "energy"
          ],
          "aka": [
            "CoQ10",
            "ubiquinone",
            "ubiquinol",
            "Q10"
          ],
          "half_life_hours": 34,
          "typical_dose_mg": 200,
          "routes": [
            "oral"
          ],
          "legal_status": "Dietary supplement (most jurisdictions); prescription cardiac medication in Japan",
          "wikidata": "Q140453",
          "pubchem_cid": "5281915",
          "cas": "303-98-0"
        },
        {
          "name": "Creatine Monohydrate",
          "slug": "creatine-monohydrate",
          "url": "https://biologicalx.com/compounds/creatine-monohydrate/",
          "category": "supplement",
          "goals": [
            "fitness",
            "cognition",
            "recovery"
          ],
          "aka": [
            "creatine"
          ],
          "half_life_hours": 3,
          "typical_dose_mg": 5000,
          "routes": [
            "oral"
          ],
          "legal_status": "Dietary supplement (most jurisdictions)",
          "wikidata": "Q408389",
          "pubchem_cid": "586",
          "cas": "57-00-1"
        },
        {
          "name": "Curcumin",
          "slug": "curcumin",
          "url": "https://biologicalx.com/compounds/curcumin/",
          "category": "natural",
          "goals": [
            "recovery",
            "longevity",
            "joint-health"
          ],
          "aka": [
            "turmeric extract",
            "diferuloylmethane"
          ],
          "half_life_hours": 7,
          "typical_dose_mg": 500,
          "routes": [
            "oral"
          ],
          "legal_status": "Dietary supplement (global)",
          "wikidata": "Q312266",
          "pubchem_cid": "969516",
          "cas": "458-37-7"
        },
        {
          "name": "DHEA",
          "slug": "dhea",
          "url": "https://biologicalx.com/compounds/dhea/",
          "category": "hormone",
          "goals": [
            "hormones",
            "longevity"
          ],
          "aka": [
            "dehydroepiandrosterone",
            "prasterone",
            "Intrarosa"
          ],
          "half_life_hours": 12,
          "typical_dose_mg": 25,
          "routes": [
            "oral",
            "vaginal",
            "topical"
          ],
          "legal_status": "OTC supplement in US (DSHEA 1994); prescription in EU, UK, Canada, Australia",
          "wikidata": "Q411733",
          "pubchem_cid": "5881",
          "cas": "53-43-0"
        },
        {
          "name": "EGCG",
          "slug": "egcg",
          "url": "https://biologicalx.com/compounds/egcg/",
          "category": "natural",
          "goals": [
            "metabolism",
            "longevity",
            "cardiovascular"
          ],
          "aka": [
            "epigallocatechin gallate",
            "green tea extract"
          ],
          "half_life_hours": 3,
          "typical_dose_mg": 400,
          "routes": [
            "oral"
          ],
          "legal_status": "Dietary supplement; warning labels required above 800 mg/day in some EU jurisdictions",
          "wikidata": "Q307091",
          "pubchem_cid": "65064",
          "cas": "989-51-5"
        },
        {
          "name": "Epitalon",
          "slug": "epitalon",
          "url": "https://biologicalx.com/compounds/epitalon/",
          "category": "peptide",
          "goals": [
            "longevity",
            "sleep",
            "circadian"
          ],
          "aka": [
            "Epithalon",
            "Ala-Glu-Asp-Gly",
            "AEDG",
            "Epithalamin (precursor extract)"
          ],
          "half_life_hours": 0.5,
          "typical_dose_mg": 5,
          "routes": [
            "subcutaneous",
            "intramuscular",
            "intranasal"
          ],
          "legal_status": "Not FDA approved; registered in Russia under domestic pharmaceutical framework; research-use-only grey market in US/EU",
          "wikidata": "Q5384126",
          "pubchem_cid": "219042",
          "cas": "307297-39-8"
        },
        {
          "name": "Fisetin",
          "slug": "fisetin",
          "url": "https://biologicalx.com/compounds/fisetin/",
          "category": "supplement",
          "goals": [
            "longevity",
            "cognition"
          ],
          "aka": [
            "3,7,3',4'-tetrahydroxyflavone"
          ],
          "half_life_hours": 2,
          "typical_dose_mg": 500,
          "routes": [
            "oral"
          ],
          "legal_status": "OTC dietary supplement",
          "wikidata": "Q230614",
          "pubchem_cid": "5281614",
          "cas": "528-48-3"
        },
        {
          "name": "GHK-Cu",
          "slug": "ghk-cu",
          "url": "https://biologicalx.com/compounds/ghk-cu/",
          "category": "peptide",
          "goals": [
            "skin",
            "wound healing",
            "hair",
            "longevity"
          ],
          "aka": [
            "Copper Peptide",
            "Glycyl-L-histidyl-L-lysine copper",
            "GHK"
          ],
          "half_life_hours": 0.5,
          "typical_dose_mg": 2,
          "routes": [
            "topical",
            "subcutaneous"
          ],
          "legal_status": "Topical cosmetics legal in most jurisdictions; injectable form not FDA approved for any indication; research-use-only grey market",
          "wikidata": "Q3104638",
          "pubchem_cid": "73587",
          "cas": "49557-75-7"
        },
        {
          "name": "GHRP-2",
          "slug": "ghrp-2",
          "url": "https://biologicalx.com/compounds/ghrp-2/",
          "category": "peptide",
          "goals": [
            "growth-hormone",
            "recovery",
            "appetite"
          ],
          "aka": [
            "Growth Hormone Releasing Peptide 2",
            "Pralmorelin",
            "KP-102",
            "GPA-748"
          ],
          "half_life_hours": 0.5,
          "typical_dose_mg": 0.1,
          "routes": [
            "subcutaneous",
            "intranasal",
            "intravenous"
          ],
          "legal_status": "Not FDA approved; approved in Japan as pralmorelin (diagnostic); research-use-only grey market in US/EU; banned by WADA",
          "wikidata": "Q7235681",
          "pubchem_cid": "9919072",
          "cas": "158861-67-7"
        },
        {
          "name": "GHRP-6",
          "slug": "ghrp-6",
          "url": "https://biologicalx.com/compounds/ghrp-6/",
          "category": "peptide",
          "goals": [
            "growth-hormone",
            "appetite",
            "recovery"
          ],
          "aka": [
            "Growth Hormone Releasing Peptide 6",
            "SKF-110679",
            "Histidyl-D-Tryptophyl-Alanyl-Tryptophyl-D-Phenylalanyl-Lysinamide"
          ],
          "half_life_hours": 0.5,
          "typical_dose_mg": 0.1,
          "routes": [
            "subcutaneous",
            "intravenous"
          ],
          "legal_status": "Not FDA approved; research-use-only grey market; banned by WADA",
          "wikidata": "Q5519921",
          "pubchem_cid": "9919072",
          "cas": "87616-84-0"
        },
        {
          "name": "Glutathione",
          "slug": "glutathione",
          "url": "https://biologicalx.com/compounds/glutathione/",
          "category": "supplement",
          "goals": [
            "liver",
            "longevity",
            "immune"
          ],
          "aka": [
            "GSH",
            "L-glutathione",
            "reduced glutathione"
          ],
          "half_life_hours": 0.5,
          "typical_dose_mg": 500,
          "routes": [
            "oral",
            "sublingual",
            "intravenous"
          ],
          "legal_status": "OTC dietary supplement",
          "wikidata": "Q116907",
          "pubchem_cid": "124886",
          "cas": "70-18-8"
        },
        {
          "name": "Hexarelin",
          "slug": "hexarelin",
          "url": "https://biologicalx.com/compounds/hexarelin/",
          "category": "peptide",
          "goals": [
            "growth-hormone",
            "recovery",
            "cardiac-research"
          ],
          "aka": [
            "Examorelin",
            "EP-23905",
            "His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2"
          ],
          "half_life_hours": 1,
          "typical_dose_mg": 0.1,
          "routes": [
            "subcutaneous",
            "intranasal",
            "intravenous"
          ],
          "legal_status": "Not FDA approved; advanced through phase 2 trials in EU but never registered; research-use-only grey market; banned by WADA",
          "wikidata": "Q5743550",
          "pubchem_cid": "3037387",
          "cas": "140703-51-1"
        },
        {
          "name": "Ipamorelin",
          "slug": "ipamorelin",
          "url": "https://biologicalx.com/compounds/ipamorelin/",
          "category": "peptide",
          "goals": [
            "growth-hormone",
            "recovery",
            "body-composition"
          ],
          "aka": [
            "NNC 26-0161",
            "Aib-His-D-2-Nal-D-Phe-Lys-NH2"
          ],
          "half_life_hours": 2,
          "typical_dose_mg": 0.2,
          "routes": [
            "subcutaneous",
            "intravenous"
          ],
          "legal_status": "Not FDA approved; advanced through phase 2b in postoperative ileus before discontinuation; research-use-only grey market; banned by WADA",
          "wikidata": "Q1666741",
          "pubchem_cid": "11338566",
          "cas": "170851-70-4"
        },
        {
          "name": "L-Theanine",
          "slug": "l-theanine",
          "url": "https://biologicalx.com/compounds/l-theanine/",
          "category": "supplement",
          "goals": [
            "cognition",
            "stress",
            "sleep"
          ],
          "aka": [
            "theanine",
            "gamma-glutamylethylamide"
          ],
          "half_life_hours": 1.5,
          "typical_dose_mg": 200,
          "routes": [
            "oral"
          ],
          "legal_status": "OTC dietary supplement",
          "wikidata": "Q909931",
          "pubchem_cid": "439378",
          "cas": "3081-61-6"
        },
        {
          "name": "Lion's Mane",
          "slug": "lions-mane",
          "url": "https://biologicalx.com/compounds/lions-mane/",
          "category": "natural",
          "goals": [
            "cognition",
            "nerve health",
            "mood"
          ],
          "aka": [
            "Hericium erinaceus",
            "Yamabushitake",
            "Bearded Tooth",
            "Hou Tou Gu"
          ],
          "half_life_hours": 6,
          "typical_dose_mg": 1000,
          "routes": [
            "oral"
          ],
          "legal_status": "Dietary supplement and food worldwide; unscheduled and unrestricted",
          "wikidata": "Q146050",
          "pubchem_cid": "",
          "cas": ""
        },
        {
          "name": "Low-Dose Naltrexone",
          "slug": "low-dose-naltrexone",
          "url": "https://biologicalx.com/compounds/low-dose-naltrexone/",
          "category": "pharmaceutical",
          "goals": [
            "immune",
            "pain"
          ],
          "aka": [
            "LDN",
            "naltrexone (low dose)"
          ],
          "half_life_hours": 4,
          "typical_dose_mg": 4.5,
          "routes": [
            "oral"
          ],
          "legal_status": "Off-label compounded prescription (naltrexone is FDA approved for opioid and alcohol use disorder at 50 mg)",
          "wikidata": "Q426444",
          "pubchem_cid": "5360515",
          "cas": "16590-41-3"
        },
        {
          "name": "Magnesium Glycinate",
          "slug": "magnesium-glycinate",
          "url": "https://biologicalx.com/compounds/magnesium-glycinate/",
          "category": "supplement",
          "goals": [
            "sleep",
            "recovery",
            "stress"
          ],
          "aka": [
            "magnesium bisglycinate"
          ],
          "half_life_hours": 5,
          "typical_dose_mg": 300,
          "routes": [
            "oral"
          ],
          "legal_status": "Dietary supplement",
          "wikidata": null,
          "pubchem_cid": "84645",
          "cas": "14783-68-7"
        },
        {
          "name": "Magnesium L-Threonate",
          "slug": "magnesium-threonate",
          "url": "https://biologicalx.com/compounds/magnesium-threonate/",
          "category": "supplement",
          "goals": [
            "cognition",
            "sleep"
          ],
          "aka": [
            "Mg-T",
            "MgT",
            "Magtein",
            "magnesium threonate"
          ],
          "half_life_hours": 4,
          "typical_dose_mg": 2000,
          "routes": [
            "oral"
          ],
          "legal_status": "OTC dietary supplement",
          "wikidata": "Q27151568",
          "pubchem_cid": "10691810",
          "cas": "778571-57-6"
        },
        {
          "name": "Melatonin",
          "slug": "melatonin",
          "url": "https://biologicalx.com/compounds/melatonin/",
          "category": "supplement",
          "goals": [
            "sleep",
            "circadian"
          ],
          "aka": [
            "N-acetyl-5-methoxytryptamine"
          ],
          "half_life_hours": 0.75,
          "typical_dose_mg": 0.5,
          "routes": [
            "oral",
            "sublingual"
          ],
          "legal_status": "OTC in US; prescription in UK, EU, Japan",
          "wikidata": "Q179243",
          "pubchem_cid": "896",
          "cas": "73-31-4"
        },
        {
          "name": "Metformin",
          "slug": "metformin",
          "url": "https://biologicalx.com/compounds/metformin/",
          "category": "pharmaceutical",
          "goals": [
            "metabolism",
            "longevity"
          ],
          "aka": [
            "Glucophage",
            "Fortamet",
            "Glumetza",
            "dimethylbiguanide"
          ],
          "half_life_hours": 6,
          "typical_dose_mg": 1500,
          "routes": [
            "oral"
          ],
          "legal_status": "Prescription only (FDA approved for type 2 diabetes 1994)",
          "wikidata": "Q19484",
          "pubchem_cid": "4091",
          "cas": "657-24-9"
        },
        {
          "name": "Methylene Blue",
          "slug": "methylene-blue",
          "url": "https://biologicalx.com/compounds/methylene-blue/",
          "category": "pharmaceutical",
          "goals": [
            "cognition",
            "mitochondrial",
            "antimicrobial"
          ],
          "aka": [
            "Methylthioninium chloride",
            "Provayblue",
            "tetramethylthionine chloride"
          ],
          "half_life_hours": 5.5,
          "typical_dose_mg": 70,
          "routes": [
            "oral",
            "intravenous"
          ],
          "legal_status": "Prescription (injectable, FDA approved); supplement form (oral) widely available; not scheduled",
          "wikidata": "Q409021",
          "pubchem_cid": "6099",
          "cas": "61-73-4"
        },
        {
          "name": "Modafinil",
          "slug": "modafinil",
          "url": "https://biologicalx.com/compounds/modafinil/",
          "category": "pharmaceutical",
          "goals": [
            "wakefulness",
            "cognition",
            "fatigue"
          ],
          "aka": [
            "Provigil",
            "Modalert",
            "Modvigil",
            "diphenylmethylsulfinyl-acetamide"
          ],
          "half_life_hours": 13,
          "typical_dose_mg": 200,
          "routes": [
            "oral"
          ],
          "legal_status": "Schedule IV (US); prescription-only globally; not a supplement",
          "wikidata": "Q422968",
          "pubchem_cid": "4236",
          "cas": "68693-11-8"
        },
        {
          "name": "MOTS-c",
          "slug": "mots-c",
          "url": "https://biologicalx.com/compounds/mots-c/",
          "category": "peptide",
          "goals": [
            "longevity",
            "metabolism",
            "mitochondrial-health"
          ],
          "aka": [
            "Mitochondrial Open Reading Frame of the Twelve S rRNA-c",
            "MOTSc"
          ],
          "half_life_hours": 0.5,
          "typical_dose_mg": 5,
          "routes": [
            "subcutaneous"
          ],
          "legal_status": "Not FDA approved; research-use-only grey market; not currently on WADA Prohibited List",
          "wikidata": "Q24832108",
          "pubchem_cid": "139599184",
          "cas": "1627580-64-6"
        },
        {
          "name": "N-Acetyl Cysteine",
          "slug": "nac",
          "url": "https://biologicalx.com/compounds/nac/",
          "category": "supplement",
          "goals": [
            "longevity",
            "recovery",
            "liver"
          ],
          "aka": [
            "NAC"
          ],
          "half_life_hours": 5.6,
          "typical_dose_mg": 1200,
          "routes": [
            "oral",
            "iv"
          ],
          "legal_status": "OTC in most jurisdictions; restricted periods in US history (FDA reclassified 2022)",
          "wikidata": "Q413299",
          "pubchem_cid": "12035",
          "cas": "616-91-1"
        },
        {
          "name": "Nicotinamide Riboside",
          "slug": "nicotinamide-riboside",
          "url": "https://biologicalx.com/compounds/nicotinamide-riboside/",
          "category": "supplement",
          "goals": [
            "longevity",
            "energy",
            "metabolism"
          ],
          "aka": [
            "NR",
            "Niagen",
            "nicotinamide riboside chloride"
          ],
          "half_life_hours": 8,
          "typical_dose_mg": 500,
          "routes": [
            "oral"
          ],
          "legal_status": "OTC dietary supplement",
          "wikidata": "Q3343054",
          "pubchem_cid": "439924",
          "cas": "1341-23-7"
        },
        {
          "name": "NMN",
          "slug": "nmn",
          "url": "https://biologicalx.com/compounds/nmn/",
          "category": "supplement",
          "goals": [
            "longevity",
            "energy",
            "metabolism"
          ],
          "aka": [
            "nicotinamide mononucleotide",
            "beta-NMN"
          ],
          "half_life_hours": 4,
          "typical_dose_mg": 250,
          "routes": [
            "oral",
            "sublingual"
          ],
          "legal_status": "Contested in US (FDA position 2022); widely sold as supplement; broadly available in EU, UK, Asia",
          "wikidata": "Q418972",
          "pubchem_cid": "14180",
          "cas": "1094-61-7"
        },
        {
          "name": "Noopept",
          "slug": "noopept",
          "url": "https://biologicalx.com/compounds/noopept/",
          "category": "nootropic",
          "goals": [
            "cognition",
            "memory",
            "stress"
          ],
          "aka": [
            "GVS-111",
            "N-phenylacetyl-L-prolylglycine ethyl ester",
            "Omberacetam"
          ],
          "half_life_hours": 0.7,
          "typical_dose_mg": 20,
          "routes": [
            "oral",
            "sublingual"
          ],
          "legal_status": "Approved in Russia and CIS states; prescription-only in UK; unscheduled and unapproved in US, EU varies",
          "wikidata": "Q4321022",
          "pubchem_cid": "183503",
          "cas": "157115-85-0"
        },
        {
          "name": "Omega-3 (EPA/DHA)",
          "slug": "omega-3",
          "url": "https://biologicalx.com/compounds/omega-3/",
          "category": "supplement",
          "goals": [
            "cardiovascular",
            "longevity",
            "cognition"
          ],
          "aka": [
            "fish oil",
            "EPA",
            "DHA",
            "marine omega-3"
          ],
          "half_life_hours": 48,
          "typical_dose_mg": 2000,
          "routes": [
            "oral"
          ],
          "legal_status": "Dietary supplement; prescription forms (icosapent ethyl, omega-3 acid ethyl esters) for severe hypertriglyceridemia",
          "wikidata": "Q207688",
          "pubchem_cid": "446284",
          "cas": "10417-94-4"
        },
        {
          "name": "PT-141",
          "slug": "pt-141",
          "url": "https://biologicalx.com/compounds/pt-141/",
          "category": "peptide",
          "goals": [
            "sexual function",
            "libido"
          ],
          "aka": [
            "Bremelanotide",
            "Vyleesi"
          ],
          "half_life_hours": 2.7,
          "typical_dose_mg": 1.75,
          "routes": [
            "subcutaneous"
          ],
          "legal_status": "Prescription only as Vyleesi; FDA-approved 2019 for HSDD in pre-menopausal women. Compounded versions sold off-label for male sexual function are research-use-only grey market.",
          "wikidata": "Q422059",
          "pubchem_cid": "9941379",
          "cas": "189691-06-3"
        },
        {
          "name": "Rapamycin",
          "slug": "rapamycin",
          "url": "https://biologicalx.com/compounds/rapamycin/",
          "category": "pharmaceutical",
          "goals": [
            "longevity",
            "immune"
          ],
          "aka": [
            "Sirolimus",
            "Rapamune"
          ],
          "half_life_hours": 62,
          "typical_dose_mg": 6,
          "routes": [
            "oral"
          ],
          "legal_status": "Prescription only (off-label for longevity)",
          "wikidata": "Q410174",
          "pubchem_cid": "5284616",
          "cas": "53123-88-9"
        },
        {
          "name": "Selank",
          "slug": "selank",
          "url": "https://biologicalx.com/compounds/selank/",
          "category": "peptide",
          "goals": [
            "cognition",
            "anxiety",
            "mood"
          ],
          "aka": [
            "TP-7",
            "Tuftsin analog"
          ],
          "half_life_hours": 0.5,
          "typical_dose_mg": 0.4,
          "routes": [
            "intranasal",
            "subcutaneous"
          ],
          "legal_status": "Approved as a prescription anxiolytic in Russia; not FDA approved; research-use-only grey market in most other jurisdictions",
          "wikidata": "Q4416793",
          "pubchem_cid": "11765600",
          "cas": "129954-34-3"
        },
        {
          "name": "Semaglutide",
          "slug": "semaglutide",
          "url": "https://biologicalx.com/compounds/semaglutide/",
          "category": "pharmaceutical",
          "goals": [
            "metabolism",
            "weight loss"
          ],
          "aka": [
            "Ozempic",
            "Wegovy",
            "Rybelsus"
          ],
          "half_life_hours": 168,
          "typical_dose_mg": 2.4,
          "routes": [
            "subcutaneous",
            "oral"
          ],
          "legal_status": "Prescription only (FDA-approved, EMA-approved)",
          "wikidata": "Q27089394",
          "pubchem_cid": "56843331",
          "cas": "910463-68-2"
        },
        {
          "name": "Semax",
          "slug": "semax",
          "url": "https://biologicalx.com/compounds/semax/",
          "category": "peptide",
          "goals": [
            "cognition",
            "neuroprotection",
            "stroke recovery"
          ],
          "aka": [
            "Met-Glu-His-Phe-Pro-Gly-Pro",
            "ACTH(4-10) Pro-Gly-Pro analog"
          ],
          "half_life_hours": 0.5,
          "typical_dose_mg": 0.6,
          "routes": [
            "intranasal"
          ],
          "legal_status": "Approved in Russia for stroke and cognitive disorders; not FDA approved; research-use-only grey market elsewhere",
          "wikidata": "Q4413083",
          "pubchem_cid": "9811102",
          "cas": "80714-61-0"
        },
        {
          "name": "Sermorelin",
          "slug": "sermorelin",
          "url": "https://biologicalx.com/compounds/sermorelin/",
          "category": "peptide",
          "goals": [
            "growth-hormone",
            "longevity",
            "recovery"
          ],
          "aka": [
            "Sermorelin acetate",
            "GRF 1-29",
            "Geref",
            "GHRH (1-29) NH2"
          ],
          "half_life_hours": 0.25,
          "typical_dose_mg": 0.3,
          "routes": [
            "subcutaneous"
          ],
          "legal_status": "FDA approved 1997 (Geref, pediatric GHD); voluntarily discontinued by Serono 2008; compounded by 503A/503B pharmacies for off-label adult use; banned by WADA",
          "wikidata": "Q416620",
          "pubchem_cid": "16129617",
          "cas": "86168-78-7"
        },
        {
          "name": "Spermidine",
          "slug": "spermidine",
          "url": "https://biologicalx.com/compounds/spermidine/",
          "category": "supplement",
          "goals": [
            "longevity",
            "cognition"
          ],
          "aka": [
            "spermidine trihydrochloride",
            "wheat-germ-extract spermidine"
          ],
          "half_life_hours": 6,
          "typical_dose_mg": 1.2,
          "routes": [
            "oral"
          ],
          "legal_status": "OTC dietary supplement (wheat-germ extract has GRAS status in US)",
          "wikidata": "Q411089",
          "pubchem_cid": "1102",
          "cas": "124-20-9"
        },
        {
          "name": "TB-500",
          "slug": "tb-500",
          "url": "https://biologicalx.com/compounds/tb-500/",
          "category": "peptide",
          "goals": [
            "recovery",
            "tendon repair",
            "wound healing"
          ],
          "aka": [
            "Thymosin Beta-4 fragment",
            "TB4-Frag",
            "Thymosin Beta 4"
          ],
          "half_life_hours": 2,
          "typical_dose_mg": 2.5,
          "routes": [
            "subcutaneous",
            "intramuscular"
          ],
          "legal_status": "Not FDA approved; research-use-only grey market; banned by WADA",
          "wikidata": "Q7799921",
          "pubchem_cid": "62707662",
          "cas": "885340-08-9"
        },
        {
          "name": "Testosterone",
          "slug": "testosterone",
          "url": "https://biologicalx.com/compounds/testosterone/",
          "category": "hormone",
          "goals": [
            "hormones",
            "sexual function",
            "body composition"
          ],
          "aka": [
            "TRT",
            "testosterone replacement therapy",
            "testosterone cypionate",
            "testosterone enanthate",
            "Androgel",
            "Testim"
          ],
          "half_life_hours": 192,
          "typical_dose_mg": 150,
          "routes": [
            "intramuscular",
            "subcutaneous",
            "topical",
            "buccal",
            "subcutaneous (pellet)",
            "oral"
          ],
          "legal_status": "Schedule III controlled substance (US); WADA banned",
          "wikidata": "Q150726",
          "pubchem_cid": "6013",
          "cas": "58-22-0"
        },
        {
          "name": "Thymosin Alpha-1",
          "slug": "thymosin-alpha-1",
          "url": "https://biologicalx.com/compounds/thymosin-alpha-1/",
          "category": "peptide",
          "goals": [
            "immune",
            "recovery",
            "antiviral"
          ],
          "aka": [
            "Talpha1",
            "Ta1",
            "Zadaxin",
            "Thymalfasin"
          ],
          "half_life_hours": 2,
          "typical_dose_mg": 1.6,
          "routes": [
            "subcutaneous",
            "intramuscular"
          ],
          "legal_status": "Approved in 35+ countries as Zadaxin (hepatitis B, hepatitis C adjunct, immune support); not FDA approved in US; compounded by 503A/503B pharmacies for off-label use; not on WADA Prohibited List",
          "wikidata": "Q913854",
          "pubchem_cid": "16130571",
          "cas": "62304-98-7"
        },
        {
          "name": "Tirzepatide",
          "slug": "tirzepatide",
          "url": "https://biologicalx.com/compounds/tirzepatide/",
          "category": "pharmaceutical",
          "goals": [
            "metabolism",
            "weight loss",
            "glycemic control"
          ],
          "aka": [
            "Mounjaro",
            "Zepbound",
            "LY3298176"
          ],
          "half_life_hours": 120,
          "typical_dose_mg": 10,
          "routes": [
            "subcutaneous"
          ],
          "legal_status": "Prescription only; FDA-approved 2022 (T2DM, Mounjaro) and 2023 (chronic weight management, Zepbound)",
          "wikidata": "Q105099794",
          "pubchem_cid": "156588324",
          "cas": "2023788-19-2"
        },
        {
          "name": "TUDCA",
          "slug": "tudca",
          "url": "https://biologicalx.com/compounds/tudca/",
          "category": "supplement",
          "goals": [
            "liver",
            "longevity",
            "mitochondrial"
          ],
          "aka": [
            "tauroursodeoxycholic acid",
            "taurine-conjugated UDCA"
          ],
          "half_life_hours": 4,
          "typical_dose_mg": 500,
          "routes": [
            "oral"
          ],
          "legal_status": "OTC dietary supplement (US); pharmaceutical in Italy and several Asian countries",
          "wikidata": "Q418751",
          "pubchem_cid": "9848818",
          "cas": "14605-22-2"
        },
        {
          "name": "Urolithin A",
          "slug": "urolithin-a",
          "url": "https://biologicalx.com/compounds/urolithin-a/",
          "category": "supplement",
          "goals": [
            "longevity",
            "muscle",
            "mitochondrial"
          ],
          "aka": [
            "UA",
            "Mitopure",
            "ellagitannin metabolite"
          ],
          "half_life_hours": 17,
          "typical_dose_mg": 500,
          "routes": [
            "oral"
          ],
          "legal_status": "OTC dietary supplement (US GRAS 2018; EFSA Novel Food 2021)",
          "wikidata": "Q27101321",
          "pubchem_cid": "5488186",
          "cas": "1143-70-0"
        },
        {
          "name": "Vitamin D3 + K2",
          "slug": "vitamin-d3-k2",
          "url": "https://biologicalx.com/compounds/vitamin-d3-k2/",
          "category": "supplement",
          "goals": [
            "bone-health",
            "longevity",
            "cardiovascular"
          ],
          "aka": [
            "cholecalciferol + menaquinone",
            "D3/K2",
            "vitamin D3 with MK-7"
          ],
          "half_life_hours": 360,
          "typical_dose_mg": 0.05,
          "routes": [
            "oral"
          ],
          "legal_status": "Dietary supplement (global)",
          "wikidata": "Q139347",
          "pubchem_cid": "5280795",
          "cas": "67-97-0"
        }
      ]
    },
    "tools": {
      "count": 8,
      "index_url": "https://biologicalx.com/tools/",
      "description": "Stateless, client-side, no-account calculators.",
      "entries": [
        {
          "name": "Reconstitution Calculator",
          "url": "https://biologicalx.com/tools/reconstitution/",
          "description": "BAC water volume + syringe units"
        },
        {
          "name": "Dosage Calculator",
          "url": "https://biologicalx.com/tools/dosage/",
          "description": "Weight-based dosing with kg/lb"
        },
        {
          "name": "Half-Life Visualizer",
          "url": "https://biologicalx.com/tools/half-life/",
          "description": "Plasma concentration over time"
        },
        {
          "name": "Cost-per-Dose",
          "url": "https://biologicalx.com/tools/cost-per-dose/",
          "description": "Cost per dose, week, month, vials"
        },
        {
          "name": "Biological Age Estimator",
          "url": "https://biologicalx.com/tools/biological-age/",
          "description": "Levine PhenoAge from 9 blood markers"
        },
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