Comparison
Bromantane vs Magnesium Glycinate
Side-by-side of Bromantane and Magnesium Glycinate. Every row below is pulled from the compound schema and will update as our data grows. For deeper reads, follow through to each compound page.
Bromantane
Bromantane, the Russian nootropic sold as Ladasten (ADK-709), acts on dopamine to cut fatigue and anxiety without classical stimulant rebound.
Magnesium Glycinate
Magnesium glycinate supplement guide: chelated bisglycinate form, 200 to 400 mg dosage, sleep architecture benefits, low GI side effects, glycine co-effect.
Effects at a glance
Bromantane
- •Russian RCT base (Voznesenskaya 2010, n=728) supports 50 mg daily for asthenia and fatigue over 4 weeks
- •Atypical actogenic mechanism: induces tyrosine hydroxylase rather than direct monoamine release
- •Subjective profile is anxiolytic plus mildly motivating, distinct from classical stimulants
- •Long half-life of around 11 hours supports once-daily morning dosing
- •WADA-banned since 1996; relevant for tested athletes
- •Western evidence base is thin; most published trials are Russian-language and not independently replicated
Magnesium Glycinate
- •Shortens sleep onset latency in older adults and in deficient populations supplementing 200 to 400 mg elemental Mg
- •Improves subjective sleep quality scores (PSQI, ISI) modestly versus placebo over 4 to 8 weeks
- •Reduces nocturnal leg cramps and exercise-induced muscle cramping in some controlled trials
- •Lowers self-reported anxiety in mild-to-moderate cases, with smaller effect than first-line pharmacotherapy
- •Glycinate form delivers fewer GI side effects than oxide or citrate at equivalent elemental doses
- •Insufficient as a stand-alone hypertension treatment; small adjunctive blood-pressure reductions only
Side-by-side
| Attribute | Bromantane | Magnesium Glycinate |
|---|---|---|
| Category | nootropic | supplement |
| Also known as | Ladasten, ADK-709, N-(4-bromophenyl)adamantan-2-amine | magnesium bisglycinate |
| Half-life (hr) ↗ | 11 | 5 |
| Typical dose (mg) ↗ | 75 | 300 |
| Dosing frequency | daily, morning | daily (often evening) |
| Routes | oral | oral |
| Onset (hr) | 3 | 1 |
| Peak (hr) | 168 | - |
| Molecular weight | 280.21 | - |
| Molecular formula | C16H20BrN | - |
| Mechanism | Indirect dopaminergic and serotonergic actogenic activity via induction of tyrosine hydroxylase and selective increases in serotonin synthesis in hippocampus and hypothalamus. | Magnesium acts as a cofactor for 300+ enzymes and as a voltage-dependent antagonist at NMDA receptors; glycine serves as an inhibitory neurotransmitter and co-agonist at glycine receptors. |
| Legal status | Approved in Russia (Ladasten); unscheduled and unapproved in US, EU, UK | Dietary supplement |
| WADA status | banned | allowed |
| DEA / Rx | Not scheduled in the US | OTC supplement |
| Pregnancy | Not recommended | Generally considered acceptable at RDA doses; consult clinician |
| CAS | 87913-26-6 | 14783-68-7 |
| PubChem CID | 9576456 | 84645 |
| Wikidata | Q4093816 | - |
Safety profile
Bromantane
Common side effects
- mild GI upset
- headache
- skin rash
- occasional insomnia at higher doses
Contraindications
- pregnancy
- lactation
- severe hepatic impairment
- severe renal impairment
- pediatric use
Interactions
- MAOIs: theoretical additive dopaminergic and serotonergic activity(major)
- levodopa and dopamine agonists: additive dopaminergic activity(moderate)
- SSRIs and other serotonergic drugs: theoretical serotonergic additivity(moderate)
- classical stimulants: theoretical additive activity, undocumented(moderate)
Magnesium Glycinate
Common side effects
- mild GI upset at high doses
- loose stools (dose-dependent, less than with oxide/citrate forms)
Contraindications
- severe renal impairment
- myasthenia gravis
- heart block
Interactions
- tetracycline and fluoroquinolone antibiotics: magnesium chelates antibiotic, reducing absorption; separate by 2+ hours(moderate)
- bisphosphonates: reduced absorption of bisphosphonate(moderate)
- potassium-sparing diuretics: possible hypermagnesemia in renal impairment(moderate)
Which Should You Take?
Magnesium Glycinate comes out ahead for most readers on the criteria we weight: 3 catalogued goals, OTC dietary supplement, oral dosing, with a Tier-A outcome catalogued. Bromantane is the right call when one of the conditionals below applies.
- → If your priority is focus or working memory, pick Bromantane.
- → If your priority is fatigue resistance, pick Bromantane.
- → If your priority is sleep onset or sleep quality, pick Magnesium Glycinate.
- → If your priority is post-training recovery, pick Magnesium Glycinate.
Edge case: If you want to avoid controlled substance, Magnesium Glycinate is the more accessible choice.
Default choice: Magnesium Glycinate. Lower friction to source, a Tier-A evidence outcome catalogued, and broader goal coverage. Reach for Bromantane only if your priority sits squarely in the goals it owns above.
This verdict is generated from each compound's schema (goals, legal status, evidence outcomes, dosing route). It updates automatically as our compound data evolves; the deeper read sits on each individual compound page.
Common questions
What is the difference between Bromantane and Magnesium Glycinate?
Bromantane and Magnesium Glycinate differ in category (nootropic vs supplement), mechanism, and typical dosing. See the side-by-side table for full details.
Which has a longer half-life, Bromantane or Magnesium Glycinate?
Bromantane half-life is 11 hours; Magnesium Glycinate half-life is 5 hours.
Can you stack Bromantane with Magnesium Glycinate?
Stack compatibility depends on mechanism overlap, legal status, and individual response. Check each compound page for specific interactions and contraindications before combining.
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