Comparison
DHEA vs GHRP-6
Side-by-side of DHEA and GHRP-6. Every row below is pulled from the compound schema and will update as our data grows. For deeper reads, follow through to each compound page.
DHEA
DHEA supplement profile: adrenal androgen precursor, typical 25-50 mg dose, DHEA-S targets, evidence for adrenal insufficiency and vaginal atrophy, side effec.
GHRP-6
First-generation hexapeptide ghrelin-receptor agonist. Pioneered the GHS-R1a pathway in the 1980s. Produces the strongest hunger response among GHRPs and a mo.
Effects at a glance
DHEA
- •Adrenal androgen precursor; serum DHEA-S declines progressively after the third decade of life
- •OTC dietary supplement in US under DSHEA 1994; prescription in EU, UK, Canada, Australia
- •FDA approved as Intrarosa (6.5 mg vaginal insert) for postmenopausal dyspareunia in 2016
- •Acts as tissue-specific prohormone converted intracrinologically to testosterone and estrogens
- •Best evidence: adrenal insufficiency replacement and vaginal atrophy; weaker on cognition and longevity
- •WADA banned in competitive sport; banned in NCAA, MLB, NFL, IOC settings
GHRP-6
- •First-generation hexapeptide ghrelin-receptor agonist; foundational to the GHRP class
- •Strongest appetite stimulation of any synthetic GHRP at equivalent GH doses
- •Produces measurable cortisol and prolactin rise alongside the GH pulse
- •Anecdotal protocols use 100 to 200 mcg subcutaneously 2 to 3 times daily on an empty stomach
- •Largely superseded by ipamorelin (cleaner profile) and GHRP-2 (stronger pulse) for body-composition use
- •Banned by WADA under S2; detection methods validated in accredited labs
Side-by-side
| Attribute | DHEA | GHRP-6 |
|---|---|---|
| Category | hormone | peptide |
| Also known as | dehydroepiandrosterone, prasterone, Intrarosa | Growth Hormone Releasing Peptide 6, SKF-110679, Histidyl-D-Tryptophyl-Alanyl-Tryptophyl-D-Phenylalanyl-Lysinamide |
| Half-life (hr) ↗ | 12 | 0.5 |
| Typical dose (mg) ↗ | 25 | 0.1 |
| Dosing frequency | daily, typically morning | 2-3x daily |
| Routes | oral, vaginal, topical | subcutaneous, intravenous |
| Onset (hr) | 1 | 0.25 |
| Peak (hr) | 1 | 0.5 |
| Molecular weight | 288.42 | 872.44 |
| Molecular formula | C19H28O2 | C46H56N12O6 |
| Mechanism | Steroid prohormone converted intracrinologically to testosterone and estrogens in target tissues; also exerts direct effects via sigma-1 receptor, GABA-A modulation, and glucocorticoid receptor interaction. | Hexapeptide agonist of GHS-R1a (ghrelin receptor). Suppresses hypothalamic somatostatin and stimulates pituitary somatotrophs, with strong central NPY/AgRP appetite signaling and modest cortisol and prolactin release. |
| Legal status | OTC supplement in US (DSHEA 1994); prescription in EU, UK, Canada, Australia | Not FDA approved; research-use-only grey market; banned by WADA |
| WADA status | banned | banned |
| DEA / Rx | OTC supplement in US (not scheduled); Rx in EU, UK, Canada, Australia | Not scheduled (research chemical) |
| Pregnancy | Contraindicated in pregnancy | Insufficient data; not recommended |
| CAS | 53-43-0 | 87616-84-0 |
| PubChem CID | 5881 | 9919072 |
| Wikidata | Q411733 | Q5519921 |
Safety profile
DHEA
Common side effects
- acne
- oily skin
- hirsutism (women)
- gynecomastia (men, higher doses)
- irritability
- insomnia
Contraindications
- hormone-sensitive cancer (breast, ovarian, prostate)
- active liver disease
- uncontrolled lipid disorder
- pregnancy and lactation
Interactions
- warfarin: case reports of altered INR; monitor(moderate)
- estrogens (HRT): additive estrogenic effect via conversion; monitor(moderate)
- insulin: may improve insulin sensitivity slightly; monitor glucose(minor)
- anastrozole: may reduce DHEA-derived estrogen; clinical relevance unclear(minor)
GHRP-6
Common side effects
- intense hunger
- water retention
- vivid dreams
- head pressure or flushing
- tingling at injection site
- transient lethargy
Contraindications
- pregnancy
- active malignancy
- history of pituitary tumor
- uncontrolled diabetes
- prolactin sensitivity
Interactions
- CJC-1295: synergistic GH release; commonly co-administered(minor)
- sermorelin: additive GH release via parallel GHRH and ghrelin pathways(minor)
- insulin: sustained GH can blunt insulin sensitivity over weeks(moderate)
- corticosteroids: blunt GH response and amplify cortisol load(moderate)
Which Should You Take?
DHEA comes out ahead for most readers on the criteria we weight: 2 catalogued goals, OTC dietary supplement, oral dosing, with a Tier-A outcome catalogued. GHRP-6 is the right call when one of the conditionals below applies.
- → If your priority is hormonal optimization, pick DHEA.
- → If your priority is healthspan extension, pick DHEA.
- → If your priority is growth-hormone axis, pick GHRP-6.
- → If your priority is appetite regulation, pick GHRP-6.
Edge case: If you want to avoid research-only / gray-market sourcing, DHEA is the more accessible choice.
Default choice: DHEA. Lower friction to source, a Tier-A evidence outcome catalogued, and broader goal coverage. Reach for GHRP-6 only if your priority sits squarely in the goals it owns above.
This verdict is generated from each compound's schema (goals, legal status, evidence outcomes, dosing route). It updates automatically as our compound data evolves; the deeper read sits on each individual compound page.
Common questions
What is the difference between DHEA and GHRP-6?
DHEA and GHRP-6 differ in category (hormone vs peptide), mechanism, and typical dosing. See the side-by-side table for full details.
Which has a longer half-life, DHEA or GHRP-6?
DHEA half-life is 12 hours; GHRP-6 half-life is 0.5 hours.
Can you stack DHEA with GHRP-6?
Stack compatibility depends on mechanism overlap, legal status, and individual response. Check each compound page for specific interactions and contraindications before combining.
Go deeper