Comparison
Fisetin vs Magnesium Glycinate
Side-by-side of Fisetin and Magnesium Glycinate. Every row below is pulled from the compound schema and will update as our data grows. For deeper reads, follow through to each compound page.
Fisetin
Fisetin is a flavonoid found in strawberries with senolytic activity in mouse models. Hickson 2019 confirmed senescent-cell clearance in human adipose tissue.
Magnesium Glycinate
Magnesium glycinate supplement guide: chelated bisglycinate form, 200 to 400 mg dosage, sleep architecture benefits, low GI side effects, glycine co-effect.
Effects at a glance
Fisetin
- •Flavonoid found in strawberries; most potent natural senolytic in screening assays (Yousefzadeh 2018)
- •Hickson 2019 confirmed reduced senescent-cell burden in human adipose tissue at 20 mg/kg pulsed for 2 days
- •Pulsed Mayo protocol (20 mg/kg/day x 2 days monthly) is the only dose with human biomarker evidence
- •Daily low-dose (100-500 mg) is mechanistically weaker but commonly used
- •Low oral bioavailability; with-fat dosing modestly improves absorption
- •Active cancer is a relative contraindication pending clearer polyphenol-treatment data
Magnesium Glycinate
- •Shortens sleep onset latency in older adults and in deficient populations supplementing 200 to 400 mg elemental Mg
- •Improves subjective sleep quality scores (PSQI, ISI) modestly versus placebo over 4 to 8 weeks
- •Reduces nocturnal leg cramps and exercise-induced muscle cramping in some controlled trials
- •Lowers self-reported anxiety in mild-to-moderate cases, with smaller effect than first-line pharmacotherapy
- •Glycinate form delivers fewer GI side effects than oxide or citrate at equivalent elemental doses
- •Insufficient as a stand-alone hypertension treatment; small adjunctive blood-pressure reductions only
Side-by-side
| Attribute | Fisetin | Magnesium Glycinate |
|---|---|---|
| Category | supplement | supplement |
| Also known as | 3,7,3',4'-tetrahydroxyflavone | magnesium bisglycinate |
| Half-life (hr) ↗ | 2 | 5 |
| Typical dose (mg) ↗ | 500 | 300 |
| Dosing frequency | pulsed 2 days/month (Mayo protocol) or daily continuous (empirical) | daily (often evening) |
| Routes | oral | oral |
| Onset (hr) | 1 | 1 |
| Peak (hr) | 4 | - |
| Molecular weight | 286.24 | - |
| Molecular formula | C15H10O6 | - |
| Mechanism | Senolytic via Bcl-2 family inhibition (Bcl-xL, Bcl-w); broad polyphenol with Nrf2 activation, mTOR inhibition at high concentrations, and antioxidant effects. | Magnesium acts as a cofactor for 300+ enzymes and as a voltage-dependent antagonist at NMDA receptors; glycine serves as an inhibitory neurotransmitter and co-agonist at glycine receptors. |
| Legal status | OTC dietary supplement | Dietary supplement |
| WADA status | allowed | allowed |
| DEA / Rx | OTC supplement | OTC supplement |
| Pregnancy | Insufficient data | Generally considered acceptable at RDA doses; consult clinician |
| CAS | 528-48-3 | 14783-68-7 |
| PubChem CID | 5281614 | 84645 |
| Wikidata | Q230614 | - |
Safety profile
Fisetin
Common side effects
- mild GI upset
- headache (rare)
Contraindications
- active cancer (theoretical, polyphenol interactions)
- pregnancy and lactation (insufficient data)
- concurrent CYP3A4-sensitive medications
Interactions
- statins (CYP3A4 substrates): theoretical reduction in statin clearance at high fisetin doses(minor)
- warfarin: theoretical CYP-mediated interaction; monitor INR if combining(moderate)
- other senolytics (rapamycin, dasatinib + quercetin): additive senolytic effect; pairing is investigational(minor)
Magnesium Glycinate
Common side effects
- mild GI upset at high doses
- loose stools (dose-dependent, less than with oxide/citrate forms)
Contraindications
- severe renal impairment
- myasthenia gravis
- heart block
Interactions
- tetracycline and fluoroquinolone antibiotics: magnesium chelates antibiotic, reducing absorption; separate by 2+ hours(moderate)
- bisphosphonates: reduced absorption of bisphosphonate(moderate)
- potassium-sparing diuretics: possible hypermagnesemia in renal impairment(moderate)
Which Should You Take?
Magnesium Glycinate comes out ahead for most readers on the criteria we weight: 3 catalogued goals, OTC dietary supplement, oral dosing, with a Tier-A outcome catalogued. Fisetin is the right call when one of the conditionals below applies.
- → If your priority is healthspan extension, pick Fisetin.
- → If your priority is focus or working memory, pick Fisetin.
- → If your priority is sleep onset or sleep quality, pick Magnesium Glycinate.
- → If your priority is post-training recovery, pick Magnesium Glycinate.
Default choice: Magnesium Glycinate. Lower friction to source, a Tier-A evidence outcome catalogued, and broader goal coverage. Reach for Fisetin only if your priority sits squarely in the goals it owns above.
This verdict is generated from each compound's schema (goals, legal status, evidence outcomes, dosing route). It updates automatically as our compound data evolves; the deeper read sits on each individual compound page.
Common questions
What is the difference between Fisetin and Magnesium Glycinate?
Fisetin and Magnesium Glycinate differ in category (supplement vs supplement), mechanism, and typical dosing. See the side-by-side table for full details.
Which has a longer half-life, Fisetin or Magnesium Glycinate?
Fisetin half-life is 2 hours; Magnesium Glycinate half-life is 5 hours.
Can you stack Fisetin with Magnesium Glycinate?
Stack compatibility depends on mechanism overlap, legal status, and individual response. Check each compound page for specific interactions and contraindications before combining.
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