Comparison
GHRP-6 vs Magnesium Glycinate
Side-by-side of GHRP-6 and Magnesium Glycinate. Every row below is pulled from the compound schema and will update as our data grows. For deeper reads, follow through to each compound page.
GHRP-6
First-generation hexapeptide ghrelin-receptor agonist. Pioneered the GHS-R1a pathway in the 1980s. Produces the strongest hunger response among GHRPs and a mo.
Magnesium Glycinate
Magnesium glycinate supplement guide: chelated bisglycinate form, 200 to 400 mg dosage, sleep architecture benefits, low GI side effects, glycine co-effect.
Effects at a glance
GHRP-6
- •First-generation hexapeptide ghrelin-receptor agonist; foundational to the GHRP class
- •Strongest appetite stimulation of any synthetic GHRP at equivalent GH doses
- •Produces measurable cortisol and prolactin rise alongside the GH pulse
- •Anecdotal protocols use 100 to 200 mcg subcutaneously 2 to 3 times daily on an empty stomach
- •Largely superseded by ipamorelin (cleaner profile) and GHRP-2 (stronger pulse) for body-composition use
- •Banned by WADA under S2; detection methods validated in accredited labs
Magnesium Glycinate
- •Shortens sleep onset latency in older adults and in deficient populations supplementing 200 to 400 mg elemental Mg
- •Improves subjective sleep quality scores (PSQI, ISI) modestly versus placebo over 4 to 8 weeks
- •Reduces nocturnal leg cramps and exercise-induced muscle cramping in some controlled trials
- •Lowers self-reported anxiety in mild-to-moderate cases, with smaller effect than first-line pharmacotherapy
- •Glycinate form delivers fewer GI side effects than oxide or citrate at equivalent elemental doses
- •Insufficient as a stand-alone hypertension treatment; small adjunctive blood-pressure reductions only
Side-by-side
| Attribute | GHRP-6 | Magnesium Glycinate |
|---|---|---|
| Category | peptide | supplement |
| Also known as | Growth Hormone Releasing Peptide 6, SKF-110679, Histidyl-D-Tryptophyl-Alanyl-Tryptophyl-D-Phenylalanyl-Lysinamide | magnesium bisglycinate |
| Half-life (hr) ↗ | 0.5 | 5 |
| Typical dose (mg) ↗ | 0.1 | 300 |
| Dosing frequency | 2-3x daily | daily (often evening) |
| Routes | subcutaneous, intravenous | oral |
| Onset (hr) | 0.25 | 1 |
| Peak (hr) | 0.5 | - |
| Molecular weight | 872.44 | - |
| Molecular formula | C46H56N12O6 | - |
| Mechanism | Hexapeptide agonist of GHS-R1a (ghrelin receptor). Suppresses hypothalamic somatostatin and stimulates pituitary somatotrophs, with strong central NPY/AgRP appetite signaling and modest cortisol and prolactin release. | Magnesium acts as a cofactor for 300+ enzymes and as a voltage-dependent antagonist at NMDA receptors; glycine serves as an inhibitory neurotransmitter and co-agonist at glycine receptors. |
| Legal status | Not FDA approved; research-use-only grey market; banned by WADA | Dietary supplement |
| WADA status | banned | allowed |
| DEA / Rx | Not scheduled (research chemical) | OTC supplement |
| Pregnancy | Insufficient data; not recommended | Generally considered acceptable at RDA doses; consult clinician |
| CAS | 87616-84-0 | 14783-68-7 |
| PubChem CID | 9919072 | 84645 |
| Wikidata | Q5519921 | - |
Safety profile
GHRP-6
Common side effects
- intense hunger
- water retention
- vivid dreams
- head pressure or flushing
- tingling at injection site
- transient lethargy
Contraindications
- pregnancy
- active malignancy
- history of pituitary tumor
- uncontrolled diabetes
- prolactin sensitivity
Interactions
- CJC-1295: synergistic GH release; commonly co-administered(minor)
- sermorelin: additive GH release via parallel GHRH and ghrelin pathways(minor)
- insulin: sustained GH can blunt insulin sensitivity over weeks(moderate)
- corticosteroids: blunt GH response and amplify cortisol load(moderate)
Magnesium Glycinate
Common side effects
- mild GI upset at high doses
- loose stools (dose-dependent, less than with oxide/citrate forms)
Contraindications
- severe renal impairment
- myasthenia gravis
- heart block
Interactions
- tetracycline and fluoroquinolone antibiotics: magnesium chelates antibiotic, reducing absorption; separate by 2+ hours(moderate)
- bisphosphonates: reduced absorption of bisphosphonate(moderate)
- potassium-sparing diuretics: possible hypermagnesemia in renal impairment(moderate)
Which Should You Take?
Magnesium Glycinate comes out ahead for most readers on the criteria we weight: 3 catalogued goals, OTC dietary supplement, oral dosing, with a Tier-A outcome catalogued. GHRP-6 is the right call when one of the conditionals below applies.
- → If your priority is growth-hormone axis, pick GHRP-6.
- → If your priority is appetite regulation, pick GHRP-6.
- → If your priority is sleep onset or sleep quality, pick Magnesium Glycinate.
- → If your priority is stress and HPA-axis regulation, pick Magnesium Glycinate.
Edge case: If you want to avoid research-only / gray-market sourcing, Magnesium Glycinate is the more accessible choice.
Default choice: Magnesium Glycinate. Lower friction to source, a Tier-A evidence outcome catalogued, and broader goal coverage. Reach for GHRP-6 only if your priority sits squarely in the goals it owns above.
This verdict is generated from each compound's schema (goals, legal status, evidence outcomes, dosing route). It updates automatically as our compound data evolves; the deeper read sits on each individual compound page.
Common questions
What is the difference between GHRP-6 and Magnesium Glycinate?
GHRP-6 and Magnesium Glycinate differ in category (peptide vs supplement), mechanism, and typical dosing. See the side-by-side table for full details.
Which has a longer half-life, GHRP-6 or Magnesium Glycinate?
GHRP-6 half-life is 0.5 hours; Magnesium Glycinate half-life is 5 hours.
Can you stack GHRP-6 with Magnesium Glycinate?
Stack compatibility depends on mechanism overlap, legal status, and individual response. Check each compound page for specific interactions and contraindications before combining.
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