Reference
Meta-analysis Master List
19 pooled-evidence references curated across our compound and topic universe. Each entry is a meta-analysis, systematic review, or pooled cohort analysis with a resolvable DOI or registry locator.
What this list is
A meta-analysis pools effect sizes across studies, weights each by inverse variance, and produces a summary estimate plus heterogeneity statistics. A systematic review applies an explicit search protocol and inclusion criteria to the same body of evidence. Both sit at the top of the standard study-design hierarchy because they aggregate signal across designs and populations, reducing single-trial bias.
Each entry below is filtered from our citation registry by a methodological keyword scan (meta-analysis, systematic review, Cochrane, pooled cohort, position stand). The list is grouped by topic, dated, and each entry links to the canonical DOI.
For the literacy floor on how to read these papers (effect sizes, I-squared, GRADE, p-value misuse), see our pillar article How to Read Health Research.
How to use it
- Start with the topic group that matches your question. Each group lists strongest-by-design first within the year-sorted order.
- For meta-analyses, check the year. A 2003 meta is still cited because the dose-response is mechanistic; a 2010 cardiovascular meta may have been superseded by a 2019 update.
- Where a meta-analysis has been overturned by a later RCT (omega-3, niacin, HRT), the relevant dissent is captured in the related article on our site, not in this list. This page is the index of pooled evidence; the articles are where contradictions live.
- Each entry has a resolvable DOI. If a link 404s, file a correction (link below) and we will fix the registry.
Cardiometabolic (4)
-
Liver aminotransferases and risk of incident type 2 diabetes: a systematic review and meta-analysis
Kunutsor et al. · 2014 · American Journal of Epidemiology
Elevated ALT/GGT/ALP each independently associate with incident T2D; supports liver-fat-as-driver hypothesis
-
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality
Emerging Risk Factors Collaboration · 2010 · The Lancet · n=160.309
Pooled cohort meta; per-SD log hs-CRP increment associates with ~37% higher CHD risk after adjustment
-
Mensink, Zock, Kester & Katan · 2003 · American Journal of Clinical Nutrition
Canonical saturated-fat-to-LDL-C dose-response meta; 1% energy SFA swap moves LDL 1.6 mg/dL
-
Cholesterol-lowering effects of dietary fiber: a meta-analysis
Brown, Rosner, Willett & Sacks · 1999 · American Journal of Clinical Nutrition
67 controlled trials; 3 g oat soluble fiber lowers LDL ~5 mg/dL
DOI: 10.1093/ajcn/69.1.30
Longevity & biological aging (3)
-
Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts
Paluch et al. · 2022 · The Lancet Public Health · n=47.471
-
Serum albumin and health in older people: Review and meta analysis.
Cabrerizo et al. · 2015 · Maturitas
Meta-analysis linking low serum albumin (<35-38 g/L) to elevated all-cause mortality and frailty in older adults
-
Red cell distribution width and mortality in older adults: a meta-analysis.
Patel et al. · 2010 · Journals of Gerontology
Each 1% rise in RDW associated with ~14% higher all-cause mortality in older adults across multiple cohorts
Fitness & resistance training (3)
-
Grgic et al. · 2018 · Sports Medicine
-
Kreider et al. · 2017 · Journal of the International Society of Sports Nutrition
The cleanest authoritative summary of ~700 trials
-
Morton et al. · 2017 · British Journal of Sports Medicine · n=1.863
Diminishing returns above ~1.6 g/kg/day
Recovery (3)
-
The effects of cold water immersion on mental health: a systematic review
Cain et al. · 2023 · Physiology & Behavior
-
Cardiovascular and other health benefits of sauna bathing: A review of the evidence
Laukkanen et al. · 2018 · Mayo Clinic Proceedings
Finnish cohort, dose-response to sauna frequency
-
Zaccaro et al. · 2018 · Frontiers in Human Neuroscience
Sleep (1)
-
Adam et al. · 2017 · Psychoneuroendocrinology
Hormones (2)
-
Levine, Joergensen, Martino-Andrade et al. · 2022 · Human Reproduction Update
2022/2023 update to Levine 2017; extends dataset to ~2019, adds non-Western cohorts, finds accelerating post-2000 decline
-
Temporal trends in sperm count: a systematic review and meta-regression analysis
Levine et al. · 2017 · Human Reproduction Update
~50% decline in sperm counts among Western men 1973-2011
Methodology & evidence appraisal (3)
-
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Guyatt, Oxman, Vist, Kunz, Falck-Ytter, Alonso-Coello & Schunemann · 2008 · BMJ
Foundational GRADE working-group paper; standard framework for confidence ratings in meta-analyses and clinical guidelines
-
Why most published research findings are false
Ioannidis · 2005 · PLoS Medicine
Canonical statistical-power and prior-probability argument for replication failure rates in clinical literature
-
Measuring inconsistency in meta-analyses
Higgins, Thompson, Deeks & Altman · 2003 · BMJ
Introduced the I-squared statistic for quantifying heterogeneity in meta-analyses
Related
- How to Read Health Research : the literacy pillar this list pairs with.
- Methodology : the editorial gates that govern every citation here.
- Research index : freshness dashboard for our article archive (180-day review window).
- All articles : topic-by-topic application of this evidence base.
Corrections
Spotted a meta-analysis that belongs here, a broken DOI, or a description that overstates a finding? Email corrections@biologicalx.com with the registry key or the DOI and we will reconcile it on the next build.