Goal

Metabolism

Glucose control, insulin sensitivity, lipid panel, body composition. Core cardiometabolic health.

Compounds

Alpha-Lipoic Acid

aka ALA / thioctic acid / R-ALA / R-lipoic acid

Alpha lipoic acid supplement guide: 600 mg/day oral dosing, R-ALA vs racemic absorption, neuropathy trial data, antioxidant mechanism, interactions.

Half-life: 0.5hr
Typical dose: 600mg

metabolism longevity neuroprotection

natural

Berberine

aka berberine HCl / berberine hydrochloride

Berberine supplement guide: 1500 mg/day lowers fasting glucose and HbA1c, AMPK activation, metformin parity in RCTs, dihydroberberine absorption.

Half-life: 3hr
Typical dose: 1500mg

metabolism longevity cardiovascular

natural

EGCG

aka epigallocatechin gallate / green tea extract

EGCG supplement guide: 300-600 mg/day green tea catechin for fat loss and cardiovascular markers. Hepatotoxicity risk above 800 mg/day fasted.

Half-life: 3hr
Typical dose: 400mg

metabolism longevity cardiovascular

pharmaceutical

Metformin

aka Glucophage / Fortamet / Glumetza / dimethylbiguanide

Metformin for longevity: biguanide mechanism of action, TAME trial status, anti-aging dosage, weight loss data, life extension evidence in non-diabetics.

Half-life: 6hr
Typical dose: 1500mg

metabolism longevity

peptide

MOTS-c

aka Mitochondrial Open Reading Frame of the Twelve S rRNA-c / MOTSc

MOTS-c peptide is a 16-amino-acid mitochondrial-derived peptide. Preclinical signals for insulin sensitivity, exercise capacity, dosage notes.

Half-life: 0.5hr
Typical dose: 5mg

longevity metabolism mitochondrial-health

supplement

Nicotinamide Riboside

aka NR / Niagen / nicotinamide riboside chloride

Nicotinamide riboside (NR) is the most-studied NAD+ precursor in humans. Sold as Niagen by Chromadex; raises plasma NAD+ 30-60% at 250-1,000 mg/day.

Half-life: 8hr
Typical dose: 500mg

longevity energy metabolism

supplement

NMN

aka nicotinamide mononucleotide / beta-NMN

NMN supplements are oral nicotinamide mononucleotide capsules sold for longevity, energy, and metabolic health. They raise plasma NAD+ 30-90% at 250-1000.

Half-life: 4hr
Typical dose: 250mg

longevity energy metabolism

pharmaceutical

Semaglutide

aka Ozempic / Wegovy / Rybelsus

Semaglutide for weight loss: GLP-1 agonist (Ozempic, Wegovy) drives 15-17% mean loss at 2.4 mg/week in STEP trials. Watch lean-mass loss.

Half-life: 168hr
Typical dose: 2.4mg

metabolism weight loss

pharmaceutical

Tirzepatide

aka Mounjaro / Zepbound / LY3298176

Tirzepatide for weight loss: dual GIP/GLP-1 agonist sold as Mounjaro and Zepbound. SURMOUNT-1 showed 22.5% mean body-weight loss at 15 mg over 72 weeks.

Half-life: 120hr
Typical dose: 10mg

metabolism weight loss glycemic control