Fisetin dosage

Protocol

1. 1

   Measure the dose

   Typical Fisetin dose is 500 mg. Use a weight-based calculator for individual adjustments.

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2. 2

   Set the frequency

   Administer pulsed 2 days/month (Mayo protocol) or daily continuous (empirical). Half-life of 2 hours anchors the dosing interval.

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3. 3

   Cycle if needed

   Pulsed senolytic dosing 2 consecutive days monthly is the protocol with human biomarker evidence

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4. 4

   Monitor for side effects

   Watch for: mild GI upset; headache (rare). Stop or reduce dose if tolerability breaks down.

Why this dose

Senolytic via Bcl-2 family inhibition (Bcl-xL, Bcl-w); broad polyphenol with Nrf2 activation, mTOR inhibition at high concentrations, and antioxidant effects.

The typical 500 mg dose is the figure most commonly used in published protocols for Fisetin. Treat the label as a starting point: body weight, training status, sleep, diet, and concurrent medications all shift the effective dose-response curve in real users.

How to administer

Fisetin is administered via the oral route. Oral dosing is straightforward: take with water, with or without food unless specifically noted.

Onset of action runs around 1 hour after administration. Peak effect lands near 4 hours post-dose. Plan the administration window so that peak effect lines up with whatever outcome you are dosing for, whether that is training, sleep, or symptom coverage.

Half-life note: Plasma half-life 1-4 hours; rapid conjugation and clearance

Cycling and tolerance

Pulsed senolytic dosing 2 consecutive days monthly is the protocol with human biomarker evidence

Effects to expect at typical dose

• Flavonoid found in strawberries; most potent natural senolytic in screening assays (Yousefzadeh 2018)
• Hickson 2019 confirmed reduced senescent-cell burden in human adipose tissue at 20 mg/kg pulsed for 2 days
• Pulsed Mayo protocol (20 mg/kg/day x 2 days monthly) is the only dose with human biomarker evidence
• Daily low-dose (100-500 mg) is mechanistically weaker but commonly used
• Low oral bioavailability; with-fat dosing modestly improves absorption
• Active cancer is a relative contraindication pending clearer polyphenol-treatment data

Side effects and interactions

Common side effects

• mild GI upset
• headache (rare)

Notable interactions

• warfarin (moderate): theoretical CYP-mediated interaction; monitor INR if combining
• statins (CYP3A4 substrates) (minor): theoretical reduction in statin clearance at high fisetin doses
• other senolytics (rapamycin, dasatinib + quercetin) (minor): additive senolytic effect; pairing is investigational

Lists above cover commonly reported and well-characterized items. They are not exhaustive: review the full Fisetin profile and discuss with a clinician familiar with your medication list before starting, particularly if you are on prescription therapy or have a chronic condition.

Regulatory snapshot

WADA status

allowed

DEA / Rx

OTC supplement

Pregnancy

Insufficient data

Legal status

OTC dietary supplement

Do not use if

• active cancer (theoretical, polyphenol interactions)
• pregnancy and lactation (insufficient data)
• concurrent CYP3A4-sensitive medications

Related research